Oral Polio Vaccine (OPV) to mitigate the risk of illness and mortality during the COVID-19 pandemic: A cluster-randomised trial in Guinea-Bissau
The results of our recent cluster-randomised trial in urban Guinea-Bissau finding sex-differential effects of OPV on morbidity and mortality in adults aged 50+.
Health effects of utilising hospital contacts to provide measles vaccination to children 9 - 59 months — a randomised controlled trial in Guinea-Bissau
Trial protocol for our ongoing trial assessing if providing missing doses of measles vaccine at curative health systems contacts can reduce the risk of subsequent illness and mortality.
The mortality effects of disregarding the strategy to save doses of measles vaccine - a cluster-randomized trial in Guinea-Bissau
Measles vaccine (MV) may improve health beyond measles protection. To avoid wastage from multi-dose vials, children in Guinea-Bissau are only measles vaccinated when aged 9-11 months and when six or more children are present. We assessed health impacts of providing MV to all measles-unvaccinated children 9-35 months in a cluster-randomised trial.
Disregarding the restrictive vial-opening policy for BCG vaccine in Guinea-Bissau: impact and cost-effectiveness for tuberculosis mortality and all-cause mortality in children aged 0-4 years
BCG vaccination is frequently delayed in low-income countries. Restrictive vial-opening policies, where a vial of BCG vaccine is not opened for few children, are a major reason for delay. During delays, children are unprotected against tuberculosis (TB) and deprived of non-specific effects of BCG.
We assessed the potential effect and cost-effectiveness of disregarding the restrictive vial-opening policy, on TB and all-cause mortality. Opening a vial of BCG for each child at the first contact with the health care system was estimated to reduce both TB mortality an all-cause mortality.
Neonatal and child mortality data in retrospective population-based surveys compared with prospective demographic surveillance: EN-INDEPTH study
Global mortality estimates remain heavily dependent on household surveys in low- and middle-income countries, where most under-five deaths occur. We compared mortality estimates for survey and HDSS data and describe age-at-death distributions during the past 5 years for children born to the same women. We assessed the proportion of HDSS-births that could be matched on month-of-birth to survey-births and used regression models to identify factors associated with matching.